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APOE4: Alzheimer’s Gene


APOE4: Alzheimer’s Gene Neutralised In The Human Brain


  • The researchers from Gladstone Institutes in the US have analysed the genes responsible for Alzheimer’s disease.
  • Researchers have identified a number of genes associated with Alzheimer’s disease. Some genes increase your likelihood of developing the disease (risk genes). Others guarantee that you will develop a disease (deterministic genes), though these are rare. However, genetic risk factors are just one of the factors involved in getting Alzheimer’s disease.

About APOE4 & APOE3 genes?

  • Having one copy of the apoE4 gene more than doubles a person’s likelihood of developing Alzheimer’s disease.
  • Having two copies of the gene increases the risk by 12-fold, as compared to the most common version of the gene, apoE3.
  • The apoE4 gene creates a protein of the same name.
  • The apoE4 protein differs from the apoE3 protein at only one point, but that single change is enough to alter its main structure and, thus, its function.
  • Researchers from the Gladstone Institutes in the US were also able to erase the damage caused by apoE4 by changing it, with a small molecule, into a harmless apoE3-like version.
  • They developed a class of compounds that can change the structure of the harmful apoE4 protein so it resembles the innocuous apoE3 protein, referred to as apoE4 “structure correctors.”

Genes control the function of every cell in your body. Some genes determine basic characteristics, such as the color of your eyes and hair. Other genes can make you more likely to develop certain diseases, including Alzheimer’s disease.



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